We have a new member in the first month of 2010. Juo-Yan Li is my third undergraduate student. Welcome.
Our new manuscript for SARS main protease has been accepted by Biophysical Journal. A great news.
Our lab has moved to the 1st floor in Traditional Medical Building A. It is a new start. Changing things, not changing minds.
Welcome Hung-Tien Kang and Jen-Kuo Wu joining our group. Both of them are undergraduate students. Young guys. Welcome.
There are two more persons joining our group. Ms. Li-Chao Chen is the third master student and Ms. Chiung-Wen Pai
is the first Ph.D. student. Welcome
Welcome Hsing-Yi Lai joining our group. He is the second master student.
New review on SARS-CoV papain-like protease accepted by Antiviral Chemistry and Chemotherapy as a Pointer Article. Xin Chen, Chi-Yuan Chou, and Gu-Gang Chang (2009) Thiopurine analog inhibitors of the SARS-CoV papain-like protease, a deubiquitinating and deISGylating enzyme. Antivir. Chem. Chemother. 19, 151-156.
New manuscript on biotin carboxylase accepted by Journal of Biological Chemistry! Chou Chi-Yuan, Yu Linda P.C., and Tong Liang. (2009)"Crystal Structure of Biotin Carboxylase in Complex with Substrates and Implications for Its Catalytic Mechanism" J. Biol. Chem. 284, 11690-11697. http://www.jbc.org/cgi/content/full/284/17/11690
Our great professor, Dr. Gu-Gang Chang, is going to retire on February 1st. He taught lots of young scientists in these years and discovered many important mechanisms on enzymology. He also published hundreds of wonderful articles which make a great impact on readers. Lets appreciate his great contribution to science and wish he and his wife can enjoy their retirement with good health!
Welcome Shiang-Chuan Chen joining our group. He is my first master student. Welcome.
New manuscript on SARS-CoV main protease accepted by Archives of Biochemistry and Biophysics. Lin, P. I., Chou, C. Y., Chang, H. C., Hsu, W. C., and Chang, G. G. (2008) Correlation between dissociation and catalysis of SARS-CoV main protease. Arch. Biochem. Biophys. (in press) doi:10.1016/j.abb.2008.01.023
New manuscript on malic enzyme accepted by Biophys. J. that provides conclusive evidence for the open form II, a molten globule state. Biophys. J. BioFAST: August 17, 2007. doi:10.1529/biophysj.107.111385 [Abstract] [Accepted Manuscript]
Pei-In has won the Poster Award at the 22th Joint Conference of Biomedical Sciences. Congratulations!
Welcome An-Chih Lai and Wei-Kuo Chung joining our group
Chi-Yuan was selected as the recipient of Taiwan Merit Scholarships and will go to the Lab of Professor Tong, Liang at Columbia University (New York). Congratulations! This collaboration already resulted in one review (Current Topics; Biochemistry 2003), two Molecular Cell (2006, 2007) and numerous other papers.
Newly accepted SARS paper from our lab.
Hui-Ping Chang, Chi-Yuan Chou, and Gu-Gang Chang (2007) Reversible Unfolding of the Severe Acute Respiratory Syndrome Coronavirus Main Protease in Guanidinium Chloride. Biophysical Journal (in press) http://www.biophysj.org/cgi/rapidpdf/biophysj.106.091736v1
Dr. Yu-Hou Chen is recruited by Genomic Research Center, Academia Sinica. Congratulations
Welcome Chung, Lo-Hsuan (Nancy) and Lee, Ming-Hsueh joining our lab
Welcome Tsai, Meng-Ying joining our group
Our new home page figure illustrates the application of the rebirth state-of-the-art analytical ultracentrifugation in analysis of protomer interactions in the SARS-CoV main protease.
Art design:
The sedimentation profiles at various time intervals look like rainbow in the sky. On the ground are interfacial structures, in which the C-terminus and N-terminus symbolize a flower and its root, respectively. We didnot use a colorful spectral rainbow for letting the final art looks like a traditional Chinese painting.
Welcome Dr. Hui-Ping Chang back to our lab with twin babies and tremendous experience.
Welcome Yi-Hui Hsieh joining our group.
Dr. Chi-Yuan Chou passed his final defense for the Ph. D. degree. He is the sixth Ph. D. student training in this lab.
Another SARS main protease paper from our lab was published.
Wen-Chi Hsu, Hui-Chuan Chang, Chi-Yuan Chou, Pui-Jen Tsai, Pei-In Lin, and Gu-Gang Chang (2005) Critical assessment of important regions in the subunit association and catalytic action of the severe acute respiratory syndrome coronavirus main protease. J. Biol. Chem. (in press) (www.jbc.org/cgi/content/abstract/M502556200v1?etoc)
Dr. Hui-Chuan Chang is recruited by the Institute of Biological Chemistry, Academia Sinica. Best wishes to Dr. Chang
As a happy end of 2004, our lab has many things to celebrate. Chi-Yuan just got a daughter, Meng-Ying got admission from Institute of Biopharmaceutical Sciences, and Pei-In got admission from Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Congratulations!
A Commentary of our upcoming ApoE paper (to be published in the Biophys. J.) appears on the web site of the International Atherosclerosis Society (http://www.athero.org/comm-index1.asp#1)
Another manuscript from this lab has been accepted on the day of Moon Festival. Chi-Yuan Chou, Yi-Ling Lin, Yu-Chyi Huang, Sheh-Yi Sheu, Ta-Hsien Lin, Huey-Jen Tsay, Gu-Gang Chang, and Ming-Shi Shiao (2004) Structural Variation in Human Apolipoprotein E3 and E4: Secondary Structure, Tertiary Structure, and Size Distribution. Biophysical Journal (in Press). The reviewer comments it as a fine manuscript that adequately applies modern biophysical analysis methods to studies of apo E3/E4 subdomains.
The first outlet of our SARS research, which is our new area at Yang-Ming, is accepted by the journal Biochemistry.
Chi-Yuan Chou, Hui-Chuan Chang, Wen-Chi Hsu, Tien-Zheng Lin, Chao-Hsiung Lin, and Gu-Gang Chang (2004) Quaternary Structure of the Severe Acute Respiratory Syndome (SARS) Coronavirus Main Protease. Biochemistry 43, 14958-14970. The spinning molecule on this page is the space-filling model of the dimeric SARS CoV main protease.
Dr. Yu-Hou Chen has completed his Ph.D. training in our lab, Congratulations!
Meng-Ying Li was selected by the NSC as the undergraduate student research participant in our lab, Congratulations!
Welcome Teh-Ming Yen, Yi-Hang Lu, Liang-Yu Chen and Pei-Ying Lin join our lab, Welcome!
Dr. Hui-Chuan Chang from our lab as recipient of the NHRI Postdoctoral Fellowship Award, congratulations!
A review article on malic enzyme was accomplished in this lab: Chang, G. G., and Tong, L. (2003) Structure and function of malic enzymes, a new class of oxidative decarboxylases. Biochemistry (in press)  (Current Topics) Get the Acrobat Preprint
Welcome back Hsu, Wen-Chi; Welcome Hung, Cheng-Hsiao and Li, Meng-Ying joining our group.
The Molecular Enzymology Laboratory web site was completely revised with AUC section added. The theme figure is the crystal structure of pigeon liver malic enzyme, the first structure solved in this lab in collaboration with Prof. Liang Tong at Columbia U.
We have three new members joining the lab. Yi-Han Li, Yen-Chun Liu from Yang-Ming and a new baby by Hui-Chuan and Zuei-Yen. Congratulations!
The Molecular Enzymology Laboratory is reallocated at National Yang-Ming University, Department of Life Science
Dr. Hui-Chih Hung is recruited by National Chung-Hsing University as Assistant Professor at the Department of Life Science. Congratulations!
Five members of our GROUP visit Columbia University and have GROUP meeting with Professor Liang Tong's GROUP at New York City discussing about the collaborations between two labs
Welcome Professor Liang Tong (Columbia University) visiting Taiwan and our lab
Welcome a little dragon joining the world. Congratulations to Guang-Yaw and Hui-Chih!
Welcome Daniel L. Floyd (from Columbia University) joining our group
Congratulation to Mr. Yu-Hou Chen for passing the qualify examination of the Ph.D. program December, 2000 Congratulations to Dr. Hui-Chih Hung as recipient of the outstanding postdoctor award from the National Health Research Institute
The whole campus of NDMC is moved to Nei-Hu, Taipei. Our new lab web site launched. The structure image of this page is a color version of figure 3 in Biochem. J. 333, 327-334 (1998), representing the active site region of eye lens delta-2 crystallin (argininosuccinate lyase). The figure was generated with RasMol program
Congratulations to Drs. Song-Ling Wang, Jehng-Kang Wang, and Shih-Ming Huang for completing their advanced Ph.D. degree training in the USA
Congratulations to Dr. Hwei-Jen Lee for completing her Ph.D. degree at the Oxford University, UK
Congratulations to Dr. Hui-Chih Hung for completing her Ph.D. degree in our lab
Our Frontiers in Sciences Program "Structure and Function Relationship of Malic Enzyme and Alkaline Phosphatase" was approved by the National Science Council
Our first lab web page launched. The strucure image of that page is a modeled structure of lens S-crystallin (Biophys. J. 76, 679-690, 1999), based on the coordinates of sigma-class glutathione S-transferase.
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